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An Estimate of the Average Number of Recessive Lethal Mutations Carried by Humans

The effects of inbreeding on human health depend critically on the number and severity of recessive, deleterious mutations carried by individuals. In humans, existing estimates of these quantities are based on comparisons between consanguineous and nonconsanguineous couples, an approach that confoun...

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Vydáno v:Genetics
Hlavní autoři: Gao, Ziyue, Waggoner, Darrel, Stephens, Matthew, Ober, Carole, Przeworski, Molly
Médium: Artigo
Jazyk:Inglês
Vydáno: Genetics Society of America 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4391560/
https://ncbi.nlm.nih.gov/pubmed/25697177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.114.173351
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