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An Estimate of the Average Number of Recessive Lethal Mutations Carried by Humans

The effects of inbreeding on human health depend critically on the number and severity of recessive, deleterious mutations carried by individuals. In humans, existing estimates of these quantities are based on comparisons between consanguineous and nonconsanguineous couples, an approach that confoun...

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Detalhes bibliográficos
Publicado no:Genetics
Main Authors: Gao, Ziyue, Waggoner, Darrel, Stephens, Matthew, Ober, Carole, Przeworski, Molly
Formato: Artigo
Idioma:Inglês
Publicado em: Genetics Society of America 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4391560/
https://ncbi.nlm.nih.gov/pubmed/25697177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.114.173351
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