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Interpreting the Dependence of Mutation Rates on Age and Time
Mutations can originate from the chance misincorporation of nucleotides during DNA replication or from DNA lesions that arise between replication cycles and are not repaired correctly. We introduce a model that relates the source of mutations to their accumulation with cell divisions, providing a fr...
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| Vydáno v: | PLoS Biol |
|---|---|
| Hlavní autoři: | , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Public Library of Science
2016
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4711947/ https://ncbi.nlm.nih.gov/pubmed/26761240 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1002355 |
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