Flubendazole demonstrates valid antitumor effects by inhibiting STAT3 and activating autophagy

BACKGROUND: Signal transducer and activator of transcription 3 (STAT3) is an oncogene, which upregulates in approximately 70% of human cancers. Autophagy is an evolutionarily conserved process which maintains cellular homeostasis and eliminates damaged cellular components. Moreover, the STAT3 signal...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Exp Clin Cancer Res
Prif Awduron: Lin, Shichong, Yang, Lehe, Yao, Yulei, Xu, Lingyuan, Xiang, Youqun, Zhao, Haiyang, Wang, Liangxing, Zuo, Zhigui, Huang, Xiaoying, Zhao, Chengguang
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BioMed Central 2019
Pynciau:
Research
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6615228/
https://ncbi.nlm.nih.gov/pubmed/31287013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-019-1303-z
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