Nano-scaled MTCA-KKV: for targeting thrombus, releasing pharmacophores, inhibiting thrombosis and dissolving blood clots in vivo

BACKGROUND: In vitro (1R,3S)-1-methyl-1,2,3,4-tetrahydro-β-carboline-3-carboxyl-Lys(Pro-Ala-Lys)-Arg-Gly-Asp-Val (MTCA-KKV) adheres activated platelets, targets P-selectin and GPIIb/IIIa. This led to the development of MTCA-KKV as thrombus targeting nano-medicine. METHODS: MTCA-KKV was characterized...

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Vydáno v:Int J Nanomedicine
Hlavní autoři: Zhao, Shurui, Li, Ze, Huang, Fei, Wu, Jianhui, Gui, Lin, Zhang, Xiaoyi, Wang, Yaonan, Wang, Xiaozhen, Peng, Shiqi, Zhao, Ming
Médium: Artigo
Jazyk:Inglês
Vydáno: Dove 2019
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6614858/
https://ncbi.nlm.nih.gov/pubmed/31308660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S206294
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