LC8/DYNLL1 is a 53BP1 effector and regulates checkpoint activation

The tumor suppressor protein 53BP1 plays key roles in response to DNA double-strand breaks (DSBs) by serving as a master scaffold at the damaged chromatin. Current evidence indicates that 53BP1 assembles a cohort of DNA damage response (DDR) factors to distinctly execute its repertoire of DSB respon...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: West, Kirk L, Kelliher, Jessica L, Xu, Zhanzhan, An, Liwei, Reed, Megan R, Eoff, Robert L, Wang, Jiadong, Huen, Michael S Y, Leung, Justin W C
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6614850/
https://ncbi.nlm.nih.gov/pubmed/30982887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz263
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