Single-molecule live cell imaging of Rep reveals the dynamic interplay between an accessory replicative helicase and the replisome

DNA replication must cope with nucleoprotein barriers that impair efficient replisome translocation. Biochemical and genetic studies indicate accessory helicases play essential roles in replication in the presence of nucleoprotein barriers, but how they operate inside the cell is unclear. With high-...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Syeda, Aisha H, Wollman, Adam J M, Hargreaves, Alex L, Howard, Jamieson A L, Brüning, Jan-Gert, McGlynn, Peter, Leake, Mark C
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6614839/
https://ncbi.nlm.nih.gov/pubmed/31028385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz298
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