Trimetazidine inhibits cardiac fibrosis by reducing reactive oxygen species and downregulating connective tissue growth factor in streptozotocin-induced diabetic rats

Diabetes may affect myocardial fibrosis through oxidative stress. Trimetazidine (TMZ) is an anti-anginal agent. The present study aimed to determine the modulatory effect of TMZ on reactive oxygen species (ROS) and connective tissue growth factor (CTGF) expression and to evaluate the potential of TM...

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Publicat a:Exp Ther Med
Autors principals: Zhao, Yunyue, Li, Suhua, Quan, Enxi, Zhang, Hui, Wu, Yongxiang, Luo, Yanting, Peng, Long, Wang, Jiarui, Zhu, Jieming, Liu, Jinlai
Format: Artigo
Idioma:Inglês
Publicat: D.A. Spandidos 2019
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6614713/
https://ncbi.nlm.nih.gov/pubmed/31363380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/etm.2019.7705
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