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Trimetazidine inhibits cardiac fibrosis by reducing reactive oxygen species and downregulating connective tissue growth factor in streptozotocin-induced diabetic rats

Diabetes may affect myocardial fibrosis through oxidative stress. Trimetazidine (TMZ) is an anti-anginal agent. The present study aimed to determine the modulatory effect of TMZ on reactive oxygen species (ROS) and connective tissue growth factor (CTGF) expression and to evaluate the potential of TM...

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Detalhes bibliográficos
Publicado no:Exp Ther Med
Main Authors: Zhao, Yunyue, Li, Suhua, Quan, Enxi, Zhang, Hui, Wu, Yongxiang, Luo, Yanting, Peng, Long, Wang, Jiarui, Zhu, Jieming, Liu, Jinlai
Formato: Artigo
Idioma:Inglês
Publicado em: D.A. Spandidos 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6614713/
https://ncbi.nlm.nih.gov/pubmed/31363380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/etm.2019.7705
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