Activation of the P38/CREB/MMP13 axis is associated with osteoarthritis

PURPOSES: Osteoarthritis (OA) is a common joint disease characterized by the degradation of articular cartilage and joint inflammation. Interleukin-1ß induces P38/cAMP response element binding protein (CREB) pathway activation, resulting in increased expression of matrix metallopeptidase-13 (MMP13)...

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Bibliografiska uppgifter
I publikationen:Drug Des Devel Ther
Huvudupphovsmän: Ji, Bin, Ma, Yan, Wang, Haimin, Fang, Xiangqian, Shi, Peihua
Materialtyp: Artigo
Språk:Inglês
Publicerad: Dove 2019
Ämnen:
Original Research
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6613348/
https://ncbi.nlm.nih.gov/pubmed/31308631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S209626
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