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Activation of the P38/CREB/MMP13 axis is associated with osteoarthritis
PURPOSES: Osteoarthritis (OA) is a common joint disease characterized by the degradation of articular cartilage and joint inflammation. Interleukin-1ß induces P38/cAMP response element binding protein (CREB) pathway activation, resulting in increased expression of matrix metallopeptidase-13 (MMP13)...
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| Publicado en: | Drug Des Devel Ther |
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| Autores principales: | , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Dove
2019
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6613348/ https://ncbi.nlm.nih.gov/pubmed/31308631 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S209626 |
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