Rac1/Pak1/p38/MMP-2 axis regulates angiogenesis in ovarian cancer

PURPOSE: Zoledronic acid (ZA) is being increasingly recognized for its anti-tumor properties, but the underlying functions are not well understood. In this study, we hypothesized that ZA inhibits ovarian cancer (OC) angiogenesis preventing Rac1 activation. EXPERIMENTAL DESIGN: The biological effects...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Gonzalez-Villasana, Vianey, Fuentes-Mattei, Enrique, Ivan, Cristina, Dalton, Heather J., Rodriguez-Aguayo, Cristian, Fernandez-de Thomas, Ricardo J., Aslan, Burcu, Monroig, Paloma del C., Velazquez-Torres, Guermarie, Previs, Rebecca A., Pradeep, Sunila, Kahraman, Nermin, Wang, Huamin, Kanlikilicer, Pinar, Ozpolat, Bulent, Calin, George, Sood, Anil K., Lopez-Berestein, Gabriel
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4417466/
https://ncbi.nlm.nih.gov/pubmed/25595279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-14-2279
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