Heparanase Promotes Tumor Growth and Liver Metastasis of Colorectal Cancer Cells by Activating the p38/MMP1 Axis

Heparanase (HPSE), the only known mammalian endoglycosidase responsible for heparan sulfate cleavage, is a multi-faceted protein affecting multiple malignant behaviors in cancer cells. In this study, we examined the expression of HPSE in different colorectal cancer (CRC) cell lines. Gene manipulatio...

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Bibliografiske detaljer
Udgivet i:Front Oncol
Main Authors: Liu, Xue, Zhou, Zhi-hang, Li, Wen, Zhang, Shi-kun, Li, Jing, Zhou, Ming-Ju, Song, Jin-Wen
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2019
Fag:
Oncology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6454005/
https://ncbi.nlm.nih.gov/pubmed/31001480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2019.00216
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