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RNF43 ubiquitinates and degrades phosphorylated E-cadherin by c-Src to facilitate epithelial-mesenchymal transition in lung adenocarcinoma

BACKGROUND: In epithelial cells, tyrosine kinases induce tyrosine phosphorylation and ubiquitination of the E-cadherin complex, which is responsible for the epithelial-mesenchymal transition (EMT). However, the precise mechanisms remain unclear. METHODS: Protein antibody microarray analysis and E3 l...

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Bibliografiske detaljer
Udgivet i:BMC Cancer
Main Authors: Zhang, Yunfeng, Sun, Liangzhang, Gao, Xiao, Guo, Aining, Diao, Yan, Zhao, Yang
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6613270/
https://ncbi.nlm.nih.gov/pubmed/31286874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-019-5880-1
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