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Cdk5 targets active Src for ubiquitin-dependent degradation by phosphorylating Src(S75)
The non-receptor tyrosine kinase Src is a critical regulator of cytoskeletal contraction, cell adhesion, and migration. In normal cells, Src activity is stringently controlled by Csk-dependent phosphorylation of Src(Y530), and by Cullin-5-dependent ubiquitinylation, which affects active Src(pY419) e...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3167940/ https://ncbi.nlm.nih.gov/pubmed/21442427 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-011-0638-1 |
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