Genome-wide CRISPR screen identifies suppressors of endoplasmic reticulum stress-induced apoptosis

Sensing misfolded proteins in the endoplasmic reticulum (ER), cells initiate the ER stress response and, when overwhelmed, undergo apoptosis. However, little is known about how cells prevent excessive ER stress response and cell death to restore homeostasis. Here, we report the identification and ch...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Panganiban, Ronald A., Park, Hae-Ryung, Sun, Maoyun, Shumyatcher, Maya, Himes, Blanca E., Lu, Quan
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2019
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6613086/
https://ncbi.nlm.nih.gov/pubmed/31213543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1906275116
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