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Learning signaling networks from combinatorial perturbations by exploiting siRNA off-target effects
MOTIVATION: Perturbation experiments constitute the central means to study cellular networks. Several confounding factors complicate computational modeling of signaling networks from this data. First, the technique of RNA interference (RNAi), designed and commonly used to knock-down specific genes,...
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| Publié dans: | Bioinformatics |
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| Auteurs principaux: | , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Oxford University Press
2019
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6612802/ https://ncbi.nlm.nih.gov/pubmed/31510678 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btz334 |
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