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Downregulation of Notch Signaling in Kras-Induced Gastric Metaplasia

Activating mutations and amplification of Kras and, more frequently, signatures for Kras activation are noted in stomach cancer. Expression of mutant Kras(G12D) in the mouse gastric mucosa has been shown to induce hyperplasia and metaplasia. However, the mechanisms by which Kras activation leads to...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Neoplasia
Prif Awduron: Chung, Wen-Cheng, Zhou, Yunyun, Atfi, Azeddine, Xu, Keli
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Neoplasia Press 2019
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6611983/
https://ncbi.nlm.nih.gov/pubmed/31276933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neo.2019.06.003
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