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High-level expression of biologically active human follicle stimulating hormone in the Chinese hamster ovary cell line by a pair of tricistronic and monocistronic vectors

Recombinant human follicle stimulating hormone (FSH), produced in Chinese hamster ovary (CHO) cells, is widely used for treatment of fertility disorders and is subject to biosimilars development. Cell lines with high specific productivities may simplify the FSH production process. Here, we used our...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Orlova, Nadezhda A., Kovnir, Sergey V., Khodak, Yulia A., Polzikov, Mikhail A., Nikitina, Victoria A., Skryabin, Konstantin G., Vorobiev, Ivan I.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6611665/
https://ncbi.nlm.nih.gov/pubmed/31276557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0219434
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