On the potential of in vitro organ-chip models to define temporal pharmacokinetic-pharmacodynamic relationships

Functional human-on-a-chip systems hold great promise to enable quantitative translation to in vivo outcomes. Here, we explored this concept using a pumpless heart only and heart:liver system to evaluate the temporal pharmacokinetic/pharmacodynamic (PKPD) relationship for terfenadine. There was a ti...

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Publicado no:Sci Rep
Main Authors: McAleer, Christopher W., Pointon, Amy, Long, Christopher J., Brighton, Rocky L., Wilkin, Benjamin D., Bridges, L. Richard, Narasimhan Sriram, Narasimham, Fabre, Kristin, McDougall, Robin, Muse, Victorine P., Mettetal, Jerome T., Srivastava, Abhishek, Williams, Dominic, Schnepper, Mark T., Roles, Jeff L., Shuler, Michael L., Hickman, James J., Ewart, Lorna
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6610665/
https://ncbi.nlm.nih.gov/pubmed/31270362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-45656-4
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