Investigation of the effect of hepatic metabolism on off-target cardiotoxicity in a multi-organ human-on-a-chip system.

Regulation of cosmetic testing and poor predictivity of preclinical drug studies has spurred efforts to develop new methods for systemic toxicity. Current in vitro assays do not fully represent physiology, often lacking xenobiotic metabolism. Functional human multi-organ systems containing iPSC deri...

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書誌詳細
出版年:Biomaterials
主要な著者: Oleaga, Carlota, Riu, Anne, Rothemund, Sandra, Lavado, Andrea, McAleer, Christopher W., Long, Christopher J., Persaud, Keisha, Narasimhan, Narasimhan Sriram, Tran, My, Roles, Jeffry, Carmona-Moran, Carlos A., Sasserath, Trevor, Elbrecht, Daniel H., Kumanchik, Lee, Bridges, Richard L., Martin, Candace, Schnepper, Mark T., Eckman, Gail, Jackson, Max, Wang, Ying I., Note, Reine, Langer, Jessica, Teissier, Silvia, Hickman, James J.
フォーマット: Artigo
言語:Inglês
出版事項: 2018
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6126670/
https://ncbi.nlm.nih.gov/pubmed/30130706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2018.07.062
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