Stereoisomerism of stapled peptide inhibitors of the p53-Mdm2 interaction: an assessment of synthetic strategies and activity profiles

All-hydrocarbon, i, i+7 stapled peptide inhibitors of the p53-Mdm2 interaction have emerged as promising new leads for cancer therapy. Typical chemical synthesis via olefin metathesis results in the formation of both E- and Z-isomers, an observation that is rarely disclosed but may be of importance...

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Foilsithe in:Chem Sci
Main Authors: Yuen, Tsz Ying, Brown, Christopher J., Xue, Yuezhen, Tan, Yaw Sing, Ferrer Gago, Fernando J., Lee, Xue Er, Neo, Jin Yong, Thean, Dawn, Kaan, Hung Yi Kristal, Partridge, Anthony W., Verma, Chandra S., Lane, David P., Johannes, Charles W.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Royal Society of Chemistry 2019
Ábhair:
Chemistry
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6610352/
https://ncbi.nlm.nih.gov/pubmed/31316744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9sc01456j
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