Skeletal Muscle–Specific Activation of G(q) Signaling Maintains Glucose Homeostasis

Skeletal muscle (SKM) insulin resistance plays a central role in the pathogenesis of type 2 diabetes. Because G-protein–coupled receptors (GPCRs) represent excellent drug targets, we hypothesized that activation of specific functional classes of SKM GPCRs might lead to improved glucose homeostasis i...

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Bibliografske podrobnosti
izdano v:Diabetes
Main Authors: Bone, Derek B.J., Meister, Jaroslawna, Knudsen, Jonas R., Dattaroy, Diptadip, Cohen, Amanda, Lee, Regina, Lu, Huiyan, Metzger, Daniel, Jensen, Thomas E., Wess, Jürgen
Format: Artigo
Jezik:Inglês
Izdano: American Diabetes Association 2019
Teme:
Pharmacology and Therapeutics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6610017/
https://ncbi.nlm.nih.gov/pubmed/30936140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db18-0796
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