Mendelian Randomization Analysis of Hemoglobin A(1c) as a Risk Factor for Coronary Artery Disease

OBJECTIVE: Observational studies show that higher hemoglobin A(1c) (A1C) predicts coronary artery disease (CAD). It remains unclear whether this association is driven entirely by glycemia. We used Mendelian randomization (MR) to test whether A1C is causally associated with CAD through glycemic and/o...

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Publicado en:Diabetes Care
Autores principales: Leong, Aaron, Chen, Ji, Wheeler, Eleanor, Hivert, Marie-France, Liu, Ching-Ti, Merino, Jordi, Dupuis, Josée, Tai, E Shyong, Rotter, Jerome I., Florez, Jose C., Barroso, Inês, Meigs, James B.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Diabetes Association 2019
Materias:
Epidemiology/Health Services Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6609962/
https://ncbi.nlm.nih.gov/pubmed/30659074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/dc18-1712
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