Mendelian Randomization Analysis of Hemoglobin A(1c) as a Risk Factor for Coronary Artery Disease

OBJECTIVE: Observational studies show that higher hemoglobin A(1c) (A1C) predicts coronary artery disease (CAD). It remains unclear whether this association is driven entirely by glycemia. We used Mendelian randomization (MR) to test whether A1C is causally associated with CAD through glycemic and/o...

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Detalhes bibliográficos
Publicado no:Diabetes Care
Main Authors: Leong, Aaron, Chen, Ji, Wheeler, Eleanor, Hivert, Marie-France, Liu, Ching-Ti, Merino, Jordi, Dupuis, Josée, Tai, E Shyong, Rotter, Jerome I., Florez, Jose C., Barroso, Inês, Meigs, James B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2019
Assuntos:
Epidemiology/Health Services Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6609962/
https://ncbi.nlm.nih.gov/pubmed/30659074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/dc18-1712
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