RUNX1-targeted therapy for AML expressing somatic or germline mutation in RUNX1

RUNX1 transcription factor regulates normal and malignant hematopoiesis. Somatic or germline mutant RUNX1 (mtRUNX1) is associated with poorer outcome in acute myeloid leukemia (AML). Knockdown or inhibition of RUNX1 induced more apoptosis of AML expressing mtRUNX1 versus wild-type RUNX1 and improved...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Blood
Prif Awduron: Mill, Christopher P., Fiskus, Warren, DiNardo, Courtney D., Qian, Yimin, Raina, Kanak, Rajapakshe, Kimal, Perera, Dimuthu, Coarfa, Cristian, Kadia, Tapan M., Khoury, Joseph D., Saenz, Dyana T., Saenz, David N., Illendula, Anuradha, Takahashi, Koichi, Kornblau, Steven M., Green, Michael R., Futreal, Andrew P., Bushweller, John H., Crews, Craig M., Bhalla, Kapil N.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society of Hematology 2019
Pynciau:
Myeloid Neoplasia
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6609954/
https://ncbi.nlm.nih.gov/pubmed/31023702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2018893982
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