The Natural Compound Climacostol as a Prodrug Strategy Based on pH Activation for Efficient Delivery of Cytotoxic Small Agents

We synthesized and characterized MOMO as a new small molecule analog of the cytotoxic natural product climacostol efficiently activated in mild extracellular acidosis. The synthesis of MOMO had a key step in the Wittig olefination for the construction of the carbon-carbon double bond in the alkenyl...

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Vydáno v:Front Chem
Hlavní autoři: Catalani, Elisabetta, Buonanno, Federico, Lupidi, Gabriele, Bongiorni, Silvia, Belardi, Riccardo, Zecchini, Silvia, Giovarelli, Matteo, Coazzoli, Marco, De Palma, Clara, Perrotta, Cristiana, Clementi, Emilio, Prantera, Giorgio, Marcantoni, Enrico, Ortenzi, Claudio, Fausto, Anna Maria, Picchietti, Simona, Cervia, Davide
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2019
Témata:
Chemistry
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6609918/
https://ncbi.nlm.nih.gov/pubmed/31316972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2019.00463
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