Climacostol reduces tumour progression in a mouse model of melanoma via the p53-dependent intrinsic apoptotic programme

Climacostol, a compound produced by the ciliated protozoan Climacostomum virens, displayed cytotoxic properties in vitro. This study demonstrates that it has anti-tumour potential. Climacostol caused a reduction of viability/proliferation of B16-F10 mouse melanoma cells, a rapidly occurring DNA dama...

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Publicat a:Sci Rep
Autors principals: Perrotta, Cristiana, Buonanno, Federico, Zecchini, Silvia, Giavazzi, Alessio, Proietti Serafini, Francesca, Catalani, Elisabetta, Guerra, Laura, Belardinelli, Maria Cristina, Picchietti, Simona, Fausto, Anna Maria, Giorgi, Simone, Marcantoni, Enrico, Clementi, Emilio, Ortenzi, Claudio, Cervia, Davide
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4895139/
https://ncbi.nlm.nih.gov/pubmed/27271364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep27281
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