Systemically administered peptain-1 inhibits retinal ganglion cell death in animal models: implications for neuroprotection in glaucoma

Axonal degeneration and death of retinal ganglion cells (RGCs) are the primary causes of vision loss in glaucoma. In this study, we evaluated the efficacy of a peptide (peptain-1) that exhibits robust chaperone and anti-apoptotic activities against RGC loss in two rodent models and in cultured RGCs....

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Bibliografiske detaljer
Udgivet i:Cell Death Discov
Main Authors: Stankowska, Dorota L., Nam, Mi-Hyun, Nahomi, Rooban B., Chaphalkar, Renuka M., Nandi, Sandip K., Fudala, Rafal, Krishnamoorthy, Raghu R., Nagaraj, Ram H.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6609721/
https://ncbi.nlm.nih.gov/pubmed/31285855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41420-019-0194-2
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