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Reduced P53 levels ameliorate neuromuscular junction loss without affecting motor neuron pathology in a mouse model of spinal muscular atrophy

Spinal Muscular Atrophy (SMA) is a childhood motor neuron disease caused by mutations or deletions within the SMN1 gene. At endstages of disease there is profound loss of motor neurons, loss of axons within ventral roots and defects at the neuromuscular junctions (NMJ), as evidenced by pathological...

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Publicat a:Cell Death Dis
Autors principals: Courtney, Natalie L., Mole, Alannah J., Thomson, Alison K., Murray, Lyndsay M.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6609617/
https://ncbi.nlm.nih.gov/pubmed/31273192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-1727-6
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