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Efficacious dose of metformin for breast cancer therapy is determined by cation transporter expression in tumours
BACKGROUND AND PURPOSE: It has been extensively reported that the leading anti‐diabetic drug, metformin, exerts significant anticancer effects. This hydrophilic, cationic drug requires cation transporters for cellular entry where it activates its intracellular target, the AMPK signalling pathway. Ho...
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| Publicado no: | Br J Pharmacol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6609538/ https://ncbi.nlm.nih.gov/pubmed/31032880 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14694 |
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