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Four Cation-Selective Transporters Contribute to Apical Uptake and Accumulation of Metformin in Caco-2 Cell Monolayers
Metformin is the frontline therapy for type II diabetes mellitus. The oral bioavailability of metformin is unexpectedly high, between 40 and 60%, given its hydrophilicity and positive charge at all physiologic pH values. Previous studies in Caco-2 cell monolayers, a cellular model of the human intes...
Tallennettuna:
| Julkaisussa: | J Pharmacol Exp Ther |
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| Päätekijät: | , , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
The American Society for Pharmacology and Experimental Therapeutics
2015
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4352590/ https://ncbi.nlm.nih.gov/pubmed/25563903 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.114.220350 |
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