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C23, an Oligopeptide Derived from Cold-inducible RNA-binding Protein, Suppresses Inflammation and Reduces Lung Injury in Neonatal Sepsis

INTRODUCTION: Neonatal sepsis remains a leading cause of infant mortality. Cold-inducible RNA binding protein (CIRP) is an inflammatory mediator that induces TNF-α production in macrophages. C23 is a CIRP-derived peptide that blocks CIRP from binding its receptor. We therefore hypothesized that trea...

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Bibliographische Detailangaben
Veröffentlicht in:J Pediatr Surg
Hauptverfasser: Denning, Naomi-Liza, Yang, Weng-Lang, Hansen, Laura, Prince, Jose, Wang, Ping
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6609502/
https://ncbi.nlm.nih.gov/pubmed/30691879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpedsurg.2018.12.020
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