TP53 mutation status divides myelodysplastic syndromes with complex karyotypes into distinct prognostic subgroups

Risk stratification is critical in the care of patients with myelodysplastic syndromes (MDS). Approximately 10% have a complex karyotype (CK), defined as more than two cytogenetic abnormalities, which is a highly adverse prognostic marker. However, CK-MDS can carry a wide range of chromosomal abnorm...

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Detalhes bibliográficos
Publicado no:Leukemia
Main Authors: Haase, Detlef, Stevenson, Kristen E., Neuberg, Donna, Maciejewski, Jaroslaw P., Nazha, Aziz, Sekeres, Mikkael A., Ebert, Benjamin L., Garcia-Manero, Guillermo, Haferlach, Claudia, Haferlach, Torsten, Kern, Wolfgang, Ogawa, Seishi, Nagata, Yasunobu, Yoshida, Kenichi, Graubert, Timothy A., Walter, Matthew J., List, Alan F., Komrokji, Rami S., Padron, Eric, Sallman, David, Papaemmanuil, Elli, Campbell, Peter J., Savona, Michael R., Seegmiller, Adam, Adès, Lionel, Fenaux, Pierre, Shih, Lee-Yung, Bowen, David, Groves, Michael J., Tauro, Sudhir, Fontenay, Michaela, Kosmider, Olivier, Bar-Natan, Michal, Steensma, David, Stone, Richard, Heuser, Michael, Thol, Felicitas, Cazzola, Mario, Malcovati, Luca, Karsan, Aly, Ganster, Christina, Hellström-Lindberg, Eva, Boultwood, Jacqueline, Pellagatti, Andrea, Santini, Valeria, Quek, Lynn, Vyas, Paresh, Tüchler, Heinz, Greenberg, Peter L., Bejar, Rafael
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6609480/
https://ncbi.nlm.nih.gov/pubmed/30635634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41375-018-0351-2
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