Hippocampal Dysregulation of Neurofibromin-Dependent Pathways Is Associated with Impaired Spatial Learning in Engrailed 2 Knock-Out Mice

Genome-wide association studies indicated the homeobox-containing transcription factor Engrailed-2 (En2) as a candidate gene for autism spectrum disorders (ASD). Accordingly, En2 knock-out (En2(−/−)) mice show anatomical and behavioral “ASD-like” features, including decreased sociability and learnin...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Provenzano, Giovanni, Pangrazzi, Luca, Poli, Andrea, Pernigo, Mattia, Sgadò, Paola, Genovesi, Sacha, Zunino, Giulia, Berardi, Nicoletta, Casarosa, Simona, Bozzi, Yuri
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6608314/
https://ncbi.nlm.nih.gov/pubmed/25274808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2894-13.2014
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