An experimental model of Braak’s pretangle proposal for the origin of Alzheimer’s disease: the role of locus coeruleus in early symptom development

BACKGROUND: The earliest brain pathology related to Alzheimer’s disease (AD) is hyperphosphorylated soluble tau in the noradrenergic locus coeruleus (LC) neurons. Braak characterizes five pretangle tau stages preceding AD tangles. Pretangles begin in young humans and persist in the LC while spreadin...

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Vydáno v:Alzheimers Res Ther
Hlavní autoři: Ghosh, Abhinaba, Torraville, Sarah E., Mukherjee, Bandhan, Walling, Susan G., Martin, Gerard M., Harley, Carolyn W., Yuan, Qi
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2019
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6607586/
https://ncbi.nlm.nih.gov/pubmed/31266535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13195-019-0511-2
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