An experimental model of Braak’s pretangle proposal for the origin of Alzheimer’s disease: the role of locus coeruleus in early symptom development

BACKGROUND: The earliest brain pathology related to Alzheimer’s disease (AD) is hyperphosphorylated soluble tau in the noradrenergic locus coeruleus (LC) neurons. Braak characterizes five pretangle tau stages preceding AD tangles. Pretangles begin in young humans and persist in the LC while spreadin...

詳細記述

保存先:
書誌詳細
出版年:Alzheimers Res Ther
主要な著者: Ghosh, Abhinaba, Torraville, Sarah E., Mukherjee, Bandhan, Walling, Susan G., Martin, Gerard M., Harley, Carolyn W., Yuan, Qi
フォーマット: Artigo
言語:Inglês
出版事項: BioMed Central 2019
主題:
Research
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6607586/
https://ncbi.nlm.nih.gov/pubmed/31266535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13195-019-0511-2
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