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An experimental model of Braak’s pretangle proposal for the origin of Alzheimer’s disease: the role of locus coeruleus in early symptom development

BACKGROUND: The earliest brain pathology related to Alzheimer’s disease (AD) is hyperphosphorylated soluble tau in the noradrenergic locus coeruleus (LC) neurons. Braak characterizes five pretangle tau stages preceding AD tangles. Pretangles begin in young humans and persist in the LC while spreadin...

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Detalhes bibliográficos
Publicado no:Alzheimers Res Ther
Main Authors: Ghosh, Abhinaba, Torraville, Sarah E., Mukherjee, Bandhan, Walling, Susan G., Martin, Gerard M., Harley, Carolyn W., Yuan, Qi
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6607586/
https://ncbi.nlm.nih.gov/pubmed/31266535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13195-019-0511-2
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