Down but Not Out: The Consequences of Pretangle Tau in the Locus Coeruleus

Degeneration of locus coeruleus (LC) is an underappreciated hallmark of Alzheimer's disease (AD). The LC is the main source of norepinephrine (NE) in the forebrain, and its degeneration is highly correlated with cognitive impairment and amyloid-beta (Aβ) and tangle pathology. Hyperphosphorylate...

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Bibliographic Details
Published in:Neural Plast
Main Authors: Chalermpalanupap, Termpanit, Weinshenker, David, Rorabaugh, Jacki M.
Format: Artigo
Language:Inglês
Published: Hindawi 2017
Subjects:
Review Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5605916/
https://ncbi.nlm.nih.gov/pubmed/29038736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2017/7829507
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