Drug‐induced increase in lysobisphosphatidic acid reduces the cholesterol overload in Niemann–Pick type C cells and mice

Most cells acquire cholesterol by endocytosis of circulating low‐density lipoproteins (LDLs). After cholesteryl ester de‐esterification in endosomes, free cholesterol is redistributed to intracellular membranes via unclear mechanisms. Our previous work suggested that the unconventional phospholipid...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:EMBO Rep
Huvudupphovsmän: Moreau, Dimitri, Vacca, Fabrizio, Vossio, Stefania, Scott, Cameron, Colaco, Alexandria, Paz Montoya, Jonathan, Ferguson, Charles, Damme, Markus, Moniatte, Marc, Parton, Robert G, Platt, Frances M, Gruenberg, Jean
Materialtyp: Artigo
Språk:Inglês
Publicerad: John Wiley and Sons Inc. 2019
Ämnen:
Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6607015/
https://ncbi.nlm.nih.gov/pubmed/31267706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201847055
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk