Drug‐induced increase in lysobisphosphatidic acid reduces the cholesterol overload in Niemann–Pick type C cells and mice

Most cells acquire cholesterol by endocytosis of circulating low‐density lipoproteins (LDLs). After cholesteryl ester de‐esterification in endosomes, free cholesterol is redistributed to intracellular membranes via unclear mechanisms. Our previous work suggested that the unconventional phospholipid...

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Veröffentlicht in:EMBO Rep
Hauptverfasser: Moreau, Dimitri, Vacca, Fabrizio, Vossio, Stefania, Scott, Cameron, Colaco, Alexandria, Paz Montoya, Jonathan, Ferguson, Charles, Damme, Markus, Moniatte, Marc, Parton, Robert G, Platt, Frances M, Gruenberg, Jean
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2019
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6607015/
https://ncbi.nlm.nih.gov/pubmed/31267706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201847055
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