α-Helical Motif as Inhibitors of Toxic Amyloid-β Oligomer Generation via Highly Specific Recognition of Amyloid Surface

Amyloid fibril surfaces can convert soluble proteins into toxic oligomers and are attractive targets for intervention of protein aggregation diseases. Thus far, molecules identified with inhibitory activity are either large proteins or flat cyclic compounds lacking in specificity. The main design di...

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Udgivet i:iScience
Main Authors: Jiang, Yixiang, Jiang, Xuehan, Shi, Xiaodong, Yang, Fadeng, Cao, Yang, Qin, Xuan, Hou, Zhanfeng, Xie, Mingsheng, Liu, Na, Fang, Qi, Yin, Feng, Han, Wei, Li, Zigang
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6606958/
https://ncbi.nlm.nih.gov/pubmed/31255986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2019.06.022
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