A glycine zipper motif mediates the formation of toxic β-amyloid oligomers in vitro and in vivo

BACKGROUND: The β-amyloid peptide (Aβ) contains a Gly-XXX-Gly-XXX-Gly motif in its C-terminal region that has been proposed to form a "glycine zipper" that drives the formation of toxic Aβ oligomers. We have tested this hypothesis by examining the toxicity of Aβ variants containing substit...

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Detalhes bibliográficos
Main Authors: Fonte, Virginia, Dostal, Vishantie, Roberts, Christine M, Gonzales, Patrick, Lacor, Pascale, Magrane, Jordi, Dingwell, Natalie, Fan, Emily Y, Silverman, Michael A, Stein, Gretchen H, Link, Christopher D
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3178497/
https://ncbi.nlm.nih.gov/pubmed/21861874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-6-61
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