(Epi)genetic regulation of CRTC1 in human eating behaviour and fat distribution

BACKGROUND: In brain, CREB-regulated transcription co-activator 1 (CRTC1) is involved in metabolic dysregulation. In humans a SNP in CRTC1 was associated to body fat percentage and two SNPs affected RNA Pol II binding and chromatin structure, implying epigenetic regulation of CRTC1. We sought to und...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Rohde, Kerstin, Keller, Maria, la Cour Poulsen, Lars, Rønningen, Torunn, Stumvoll, Michael, Tönjes, Anke, Kovacs, Peter, Horstmann, Annette, Villringer, Arno, Blüher, Matthias, Böttcher, Yvonne
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
Assuntos:
Research paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6606956/
https://ncbi.nlm.nih.gov/pubmed/31153815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2019.05.050
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