Resistance to the Tat Inhibitor Didehydro-Cortistatin A Is Mediated by Heightened Basal HIV-1 Transcription

Human immunodeficiency virus type 1 (HIV-1) Tat binds the viral RNA structure transactivation-responsive element (TAR) and recruits transcriptional cofactors, amplifying viral mRNA expression. The Tat inhibitor didehydro-cortistatin A (dCA) promotes a state of persistent latency, refractory to viral...

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Detalhes bibliográficos
Publicado no:mBio
Main Authors: Mousseau, Guillaume, Aneja, Rachna, Clementz, Mark A., Mediouni, Sonia, Lima, Noemia S., Haregot, Alexander, Kessing, Cari F., Jablonski, Joseph A., Thenin-Houssier, Suzie, Nagarsheth, Nisha, Trautmann, Lydie, Valente, Susana T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6606815/
https://ncbi.nlm.nih.gov/pubmed/31266880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.01750-18
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