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Lactate from astrocytes fuels learning-induced mRNA translation in excitatory and inhibitory neurons
Glycogenolysis and lactate transport from astrocytes to neurons is required for long-term memory formation, but the role of this lactate is poorly understood. Here we show that the Krebs cycle substrates pyruvate and ketone body B3HB can functionally replace lactate in rescuing memory impairment cau...
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| Publicado no: | Commun Biol |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6606643/ https://ncbi.nlm.nih.gov/pubmed/31286064 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-019-0495-2 |
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