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Norepinephrine stimulates glycogenolysis in astrocytes to fuel neurons with lactate

The mechanism of rapid energy supply to the brain, especially to accommodate the heightened metabolic activity of excited states, is not well-understood. We explored the role of glycogen as a fuel source for neuromodulation using the noradrenergic stimulation of glia in a computational model of the...

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Detalhes bibliográficos
Publicado no:PLoS Comput Biol
Main Authors: Coggan, Jay S., Keller, Daniel, Calì, Corrado, Lehväslaiho, Heikki, Markram, Henry, Schürmann, Felix, Magistretti, Pierre J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6160207/
https://ncbi.nlm.nih.gov/pubmed/30161133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1006392
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