Lactate from astrocytes fuels learning-induced mRNA translation in excitatory and inhibitory neurons

Glycogenolysis and lactate transport from astrocytes to neurons is required for long-term memory formation, but the role of this lactate is poorly understood. Here we show that the Krebs cycle substrates pyruvate and ketone body B3HB can functionally replace lactate in rescuing memory impairment cau...

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Bibliographic Details
Published in:Commun Biol
Main Authors: Descalzi, Giannina, Gao, Virginia, Steinman, Michael Q., Suzuki, Akinobu, Alberini, Cristina M.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6606643/
https://ncbi.nlm.nih.gov/pubmed/31286064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-019-0495-2
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