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Molecular tuning of farnesoid X receptor partial agonism
The bile acid-sensing transcription factor farnesoid X receptor (FXR) regulates multiple metabolic processes. Modulation of FXR is desired to overcome several metabolic pathologies but pharmacological administration of full FXR agonists has been plagued by mechanism-based side effects. We have devel...
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| Publicat a: | Nat Commun |
|---|---|
| Autors principals: | , , , , , , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group UK
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6606567/ https://ncbi.nlm.nih.gov/pubmed/31266946 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10853-2 |
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