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Palladium-catalyzed coupling reactions on functionalized 2-trifluoromethyl-4-chromenone scaffolds. Synthesis of highly functionalized trifluoromethyl-heterocycles

The chromenone core is a ubiquitous group in biologically-active natural products and has been extensively used in organic synthesis. Fluorine derived compounds, including those with a trifluoromethyl group (-CF(3)), have shown enhanced biological activities in numerous pharmaceuticals compared with...

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Publicat a:Synthesis (Stuttg)
Autors principals: Izquierdo, Javier, Jain, Atul D., Abdulkadir, Sarki A., Schiltz, Gary E.
Format: Artigo
Idioma:Inglês
Publicat: 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6605783/
https://ncbi.nlm.nih.gov/pubmed/31274934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1055/s-0037-1610669
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