Lysolipid receptor cross-talk regulates lymphatic endothelial junctions in lymph nodes

Sphingosine 1-phosphate (S1P) and lysophosphatidic acid (LPA) activate G protein–coupled receptors (GPCRs) to regulate biological processes. Using a genome-wide CRISPR/dCas9–based GPCR signaling screen, LPAR1 was identified as an inducer of S1PR1/β-arrestin coupling while suppressing Gαi signaling....

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Detalhes bibliográficos
Publicado no:J Exp Med
Principais autores: Hisano, Yu, Kono, Mari, Cartier, Andreane, Engelbrecht, Eric, Kano, Kuniyuki, Kawakami, Kouki, Xiong, Yanbao, Piao, Wenji, Galvani, Sylvain, Yanagida, Keisuke, Kuo, Andrew, Ono, Yuki, Ishida, Satoru, Aoki, Junken, Proia, Richard L., Bromberg, Jonathan S., Inoue, Asuka, Hla, Timothy
Formato: Artigo
Idioma:Inglês
Publicado em: Rockefeller University Press 2019
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6605750/
https://ncbi.nlm.nih.gov/pubmed/31147448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20181895
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