Patterned, But Not Tonic, Optogenetic Stimulation in Motor Thalamus Improves Reaching in Acute Drug-Induced Parkinsonian Rats

High-frequency deep brain stimulation (DBS) in motor thalamus (Mthal) ameliorates tremor but not akinesia in Parkinson's disease. The aim of this study was to investigate whether there are effective methods of Mthal stimulation to treat akinesia. Glutamatergic Mthal neurons, transduced with cha...

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Pubblicato in:J Neurosci
Autori principali: Seeger-Armbruster, Sonja, Bosch-Bouju, Clémentine, Little, Shane T.C., Smither, Roseanna A., Hughes, Stephanie M., Hyland, Brian I., Parr-Brownlie, Louise C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2015
Soggetti:
Brief Communications
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6605530/
https://ncbi.nlm.nih.gov/pubmed/25609635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3277-14.2015
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